Benefits and harms of trisodium citrate


The benefits of sodium tricitrate in the industry are especially specific to the pharmaceutical and medical industries. This substance is widely used in medicine and food science as an aid or additive. Sodium tricitrate is also widely used in phosphate-free detergents and cleaners.

Since citric acid is a natural compound and ubiquitous metabolite of living organisms, it is not surprising that its environmental behavior is very favorable. In fact, this complex material is easily biodegradable for aquatic organisms.

Sodium tricitrate is the sodium salt of citric acid. It is usually used in food as a flavor enhancer or preservative. It makes the food taste sour and slightly salty. The benefits and harms of sodium citrate are due to its widespread use.


Benefits of trisodium citrate in the body


Sodium tricitrate makes the blood and urine more alkaline or acidic. Trisodium citrate is significantly associated with decreased urinary pH and urinary uric acid excretion and decreased serum uric acid levels in subjects treated with allopurinol.

This combined approach also effectively improves renal glomerular filtration in a number of patients with reduced renal function. Therefore, the use of citrate with allopurinol is useful for the treatment of patients with hyperuricemia.

To better understand how to treat distal renal tubular acidosis (dRTA), the kidneys have many important functions. One of them is maintaining acid-base balance (as opposed to acid) by removing and filtering acids from the blood and through the urine. Acidosis occurs when the kidneys are unable to effectively remove acids from the bloodstream.

The formation of acids in the blood causes an imbalance called “acidosis” or “metabolic acidosis”. Metabolic acidosis can lead to serious health problems and requires immediate medical attention.

It can also cause kidney stones, brittle bones, hearing loss, digestive problems, and other medical problems. Not everyone living with dRTA experiences the same health problems.

The main goals of treatment are to restore and maintain the natural balance of acid and base, while trying to reduce and prevent heart, bone and kidney problems.

The main treatment for dRTA consists of alkaline agents used to reduce the acidification of the blood. Alkaline agents can include sodium bicarbonate, potassium bicarbonate, sodium citrate, or potassium citrate.

Sodium bicarbonate plays an important role in the treatment of primary dRTA by helping to reduce blood acidity (pH). As with any medication, you should not take sodium bicarbonate or other medications unless your healthcare provider recommends it. If sodium bicarbonate is not effective or tolerated, sodium bicarbonate can be used.

Potassium bicarbonate or potassium tricitrate can be used when blood potassium levels are low. In some people, the level of calcium in the urine is high (hypercalciuria) or there are calcium kidney stones.

Citrate is converted to bicarbonate in the body and helps correct acidosis in the blood. In addition, citrate helps prevent calcium deposits in the kidneys. Sodium (found in sodium bicarbonate, sodium citrate, or other sodium salts) can increase blood and urine calcium levels.

Reducing acid levels by alkaline agents can also help correct imbalances in other electrolytes such as potassium and phosphorus. Correcting this imbalance may help reduce the risk of bone disease and prevent kidney stones.

However, not all patients respond to these treatments in the same way. How the treatment works can depend on a number of factors such as age, stage of the disease, general health and other underlying conditions. It also depends on whether someone stays with their treatment plan and takes the medication as prescribed.


Benefits of trisodium citrate in blood coagulation


Trisodium citrate is an anticoagulant used to clot and collect blood. The final concentration of citrate in blood compounds is the highest in plasma products. Normally, the liver rapidly metabolizes the injected citrate. However, during massive blood transfusions, the liver’s capacity for this transfusion may be excessive.


Benefits of sodium tricitrate


Citrate forms a calcium complex that reduces ionized calcium and leads to hypocalcemia. Although transient hypocalcemia is usually well tolerated, nerve cell membranes may be affected, causing peripheral or acral paresthesia. Clinical manifestations may include lightheadedness and tremors.

Severe hypocalcemia can cause persistent muscle spasms, and if left untreated, it can progress to tetanus with spasms in several muscle groups. It is important to know the early signs of hypocalcemia before starting treatment. Oral administration of calcium in antacids or milk tablets is usually used for mild citrate toxicity.

Hemodialysis and treatments related to kidney failure include blood circulation outside the body. This circuit outside the body, the dialysis machine and its connections to the body, is a non-physiological and coagulation environment.

Anticoagulants, which temporarily inhibit the normal clotting process, are used to prevent blood clots in patients as they flow from this circuit to the outside of the body. In the past, heparin was the only anticoagulant used for this purpose, and while it remains the standard anticoagulant, there are other options that may be more appropriate in some situations.

Sodium citrate is one of these alternatives.

Sodium intake is not safe. There are potentially harmful metabolic changes, including acid-base imbalances, that can be associated with sodium citrate anticoagulants.


Benefits of trisodium citrate in cellular metabolism


Citrate is an important intermediate in the tricarboxylic acid cycle, which plays an important role in cell metabolism. Under normal physiological conditions, ATP production through oxidative phosphorylation in mitochondria is an efficient and primary metabolic process in which ATP molecules produce much more than a certain amount of glucose from glycolysis. In contrast, most cancer cells exhibit high levels of glycolysis to generate ATP to meet their energy needs.

Cancer cell metabolism is often referred to as the “Warburg effect”. Cancer cells mainly metabolize glucose through glycolysis and scavenge large amounts of macromolecular precursors, including acetyl CoA, to produce fatty acids, nonessential amino acids, and nucleotides.


Sodium tricitrate in medicines


When glycolysis occurs in this way, cancer cells ferment in a process called “aerobic glycolysis,” even if there is no mitochondrial dysfunction. Therefore, any inhibition of glycolysis may completely limit or even stop oncogene proliferation and lead to cell death.

ATP-deficient cells often undergo apoptosis. Induction of cell apoptosis by citrate has been demonstrated in single-celled organisms as well as cancer cells.

Be sure to inform your doctor before taking citric acid and trisodium citrate if you are pregnant.

Citrate is a safe and effective anticoagulant.


Disadvantages of trisodium citrate


As a food additive, sodium citrate is not bad for you because it is used in small amounts. But you should be careful when using it as a medicine. It can interact with a variety of medications and can harm people who already have certain conditions, including hyperkalemia.

When used as a medicine, sodium citrate treats kidney problems (such as kidney stones) and metabolic acidosis. In simpler terms, it is the combination of excess acid in body fluids. Sodium citrate is alkaline, so it has the ability to stabilize body systems that are too acidic.

Sodium tricitrate is not completely safe, it interacts with several different types of drugs, especially aluminum drugs. Additionally, people with hyperkalemia (too much potassium in the blood) or heart problems should avoid sodium tricitrate.

In addition, it may cause hypernatremia, which is too much sodium in the blood. Symptoms of hypernatremia include drowsiness and weakness. In severe cases, it can even lead to seizures and death.

Finally, sodium tricitrate may cause an allergic reaction in some people. As with any medication, talk to your doctor before taking sodium citrate if you have any other medical conditions or are taking any other medications.

Short-term side effects of sodium tricitrate may include allergic reaction, dizziness, weakness and restlessness.

The purpose of this article and presenting these points is that if we are familiar with the benefits and harms of sodium tricitrate, we can better use this substance as a food additive as well as medicine.



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